Evolutionary programming as a platform for in silico metabolic engineering. (2014) A Systems Approach to Predict Oncometabolites via Context-Specific Genome-Scale Metabolic Networks. Nam H, Campodonico M, Bordbar A, Hyduke DR, Kim S, et al.We would like to investigate the feasibility of such biological computer taking into account different layers of information. Starting from a recently published work on metabolic machines we would like to compute using additional layers of biological information, such as methylation and protein protein interactions. By turning on a gene set, we turn on the chemical reaction associated with it. Each combination of genes is coded as a string of bits each of which represents a gene set. The genome sequence is thought of as an executable code specified by a set of commands in a sort of ad-hoc low-level programming language. bacteria) as a living computer, and we are able to program it in order to obtain desired outputs. In this work, we consider the biochemical pathway in unicellular organisms (e.g. Thus, in a biochemical pathway, an enzyme reads the amount of reactants (substrates) and converts them in products. a processing unit, able to transform an input into an output signal. Moreover, a protein can be thought of as a computational element, i.e. During his studies, he presented a work about a mathematical and computational model of the morphogenesis process, in which chemical substances react together. If Turing were a first-year graduate student interested in computers, he would probably migrate into the field of computational biology. My suggested approach would be R both for evaluation and as a dataset since it has easily accessible source code and is good for statistics, but there are many reasonable approaches.Ĭomputing with multi-omics condition-specific Turing machines The starting point would be to extract a set of simple features, explore their relationships and try to predict metadata like author and date of writing, before either generalizing to more languages or developing more in depth features and more specific hints and advice. This project is about using a machine learning approach to explore these properties of code. Tools like lint and style checkers can be used to check code against manually curated, strict style rules, like spacing style, but when a human reads code to assess quality we tend to also look for subtler and more context specific cues, such as function size and variable descriptiveness. Multi layer and Deep Mining of comorbidities.Computing with multi-omics condition-specific Turing machines.
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So, if you do forget to charge it, you can always just switch to a wired connection. You can connect it via the ultra fast SLIPSTREAM WIRELESS technology, or through a Bluetooth connection, or you can go with a wired USB connection as well. The Dark Core also brings versatility to the way you connect it to your gaming computer. The sensor will allow you to adjust your DPI in 1-step increments, giving you incredibly precise control over your sensitivity levels. The Dark Core has the same PixArt PAW3392 18,000 DPI sensor that comes on the two mice listed above. The bottom line here, though, is that if you’re looking for a high-end mouse that will give you a ton of extra programmable buttons, the Scimitar is not just the best Corsair option, it is one of the better MMO mouse options currently on the market.Ĭorsair has a handful of solid wireless gaming mouse options, but their top wireless mouse is the Dark Core RGB Pro SE. However, that is to be expected from an MMO-style mouse with all of those extra buttons added. It weighs a total of 147 grams, making it the heaviest option on this list. The Scimitar is available in all black or black and yellow, it comes with RGB lighting, and an 18,000 DPI sensor (adjustable by 1 DPI). With 17 different programmable buttons-including 12 buttons on the side of the mouse-and three customizable profiles, the Corsair Scimitar will allow you to take your MMO-gaming experience to the next level. Overall, though, the Nightsword is one of the best mouse options from Corsair and, if you don’t mind spending ~$70 to get a high-end gaming mouse, it is an option you’ll want to consider.įor those of you that primarily play MMO games, or other games that benefit from having a lot of macro keys available, the best option for you from Corsair will likely be the Scimitar Elite RGB. This mouse is a bit on the bigger side, though, so if you don’t have bigger hands, you might want to look at some smaller options. It also comes with 10 fully-programmable buttons, rubber grips, and Omron switches. The Nightsword is RGB-friendly (four-zone RGB lighting) and it is a wired mouse. These two features will allow you to find very specific feels for your mouse sensitivity and movement, which will ultimately give you better in-game control. However, it comes with Corsair’s custom PixArt PMY3391 18,000 DPI optical sensor (which gives you the ability to adjust the DPI settings by 1 step increments) and the ability to adjust the weight of the mouse from as low as 119 grams to as high as 141 grams. At just under $70, it is one of the more expensive wired mice on the market. THX Ltd.Corsair’s Nightsword RGB gaming mouse is our pick for the best Corsair mouse.Intel 14th Gen Raptor Lake Refresh Full Lineup Leaks Out.AMD Ryzen 8000 "Granite Ridge" Desktop CPUs Could Utilize Same IO Die as Ryzen 7000.NVIDIA Announces DLSS 3.5 Ray Reconstruction Technology, Works on GeForce 20 and Newer.AMD Unveils Radeon RX 7800 XT and RX 7700 XT Graphics Cards.NVIDIA BIOS Signature Lock Broken, vBIOS Modding and Crossflash Enabled by Groundbreaking New Tools.AMD Announces FidelityFX Super Resolution 3 (FSR 3) Fluid Motion Rivaling DLSS 3, Broad Hardware Support.Sep 6th, 2023 Sapphire Radeon RX 7800 XT Nitro+ Review - Fantastic Overclocking.Aug 21st, 2023 Patriot Viper Xtreme 5 RGB DDR5-8000 C元8 2x 16 GB Review.Sep 4th, 2023 Starfield: FSR 2.2 Review.Aug 7th, 2023 Baldur's Gate 3 Benchmark Test & Performance Analysis Review.Aug 23rd, 2023 Immortals of Aveum Benchmark Test and Performance Analysis Review - Optimization Fail.Aug 16th, 2023 Upcoming Hardware Launches 2023 (Updated Aug 2023).Sep 8th, 2023 Starfield: DLSS Community Patch Review.Aug 28th, 2023 Armored Core VI Fires of Rubicon Benchmark Test & Performance Analysis Review.Sep 6th, 2023 AMD Radeon RX 7800 XT Review.Meet the Harpoon, Corsair's latest addition to their range with a promise to perform well at a low price. Corsair has now decided they had to expand their market by releasing something that will allow people to game with their peripherals without it breaking the bank. When looking at mice, Corsair has managed to become one of the top brands for the high-end market, but there are very few Corsair mice under the $50 mark in fact, off the top of my head, there is only the Katar. The success of a company depends very much on having the right image and releasing products that suit a wide range of customers and their different budgets. Whether you use their cases, power supplies, RAM, fans, keyboards, headsets, or mice, there is pretty much something for everyone. I think most of us have owned products by them at one point or another and love or hate them - they are one of the market leaders and are continuously pushing the industry forward. There are not many companies that are as well known as Corsair. How sleep works, and how it affects brain function Teens' desire to stay up late and sleep in is completely natural. One interesting thing that science has shown us is that the circadian rhythm (our bodies' natural clock cycle that determines when we sleep) is different for teenagers than younger children and adults. School-aged children (ages six to 12) typically need nine to 12 hours of sleep per night, and teenagers need between eight and 10 hours of sleep a night. Just after they are born, babies might need to sleep up to 17 hours a day, and they will not reach the seven-to-nine-hours range until the end of adolescence. If you sleep more than that, it is worth talking with a doctor because oversleeping can be bad for you as well. You might wonder what a normal amount of sleep is or if you are getting enough sleep.ĭoctors and researchers recommend between seven and nine hours of sleep per night for adults. Research by my own laboratory, the Theoretical and Applied Neuroscience Laboratory, demonstrated that sleep is the single biggest predictor of your brain's ability to form new memories. One of the most common signs of having a sleep debt is feeling like you are in a brain fog, where things are not as clear and focused as they should be.Ī lack of sleep can also make us more emotional and can contribute to depression.įurther, having a sleep debt can impair all of your brain's systems - the ones that support perception, memory, attention, decision-making and even learning.Īs a neuroscientist, I am extremely interested in the factors that impact brain health and function. ( Adobe Stock)Īnd living with a sleep debt has a negative impact on brain function. Having a sleep debt can impair all of your brain's systems - the ones that support perception, memory, attention, decision-making and even learning. The free version contains the above features while the pro version ($30. 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Hard disks with bad sectors mean the disk is not safe to store data it will eventually lead to the important data loss of the hard disk or partition as well as errors with running files, and the hard disk speed will slow down significantly, and blue screen errors may also occur. Free Disk Scanner Portable Edition Free Disk Partition Wiper Portable. Disk Partition Expert: Free Pro Server Enterprise Unlimited Edition, all editions have portables ones. Hard disk bad sectors is the most common problems of the hard disk. Product Size: around 3MB, real portable size, not the so-called portable version misused by other tools. SeptemMacrorit Disk Scanner Portable is a smart bad sector scanning software that can help you quickly test the disk and mark the location of bad sectors. Bad sectors are little clusters of data on your hard disk that cannot be read. Macrorit portable tools: All products have portable edition. It can help you quickly test the disk and mark the location of bad sectors. Macrorit Macrorit Disk Scanner is a smart bad sector scanning software that can help you quickly test the disk and mark the location of bad sectors.Hard. Hard disk "bad sectors" is the most common hard disk problem. Portable Macrorit Disk Scanner is a smart disk bad sector scanning software. Macrorit Disk Scanner is a smart bad sector scanning software that can help you quickly test the disk and mark bad sectors' location. That is why I chose to make the “Problem” box explicit and not a derivative of something else like Value Proposition. “A problem well stated is a problem half-solved.” I attribute a significant contributor to this failure to a lack of proper “problem understanding” from the start. Most startups fail, not because they fail to build what they set out to build but because they waste time, money, and effort in building the wrong product. Because the canvas is already quite space-constrained, it was important to maximize the signal-to-noise ratio. I found the initial Business Model Canvases I created back in August 2009 missing things I’d consider very high risk, while other things on the canvas didn’t register as high enough risk. RiskĪ state of uncertainty where some of the possibilities involve a loss, catastrophe, or other undesirable outcome. The lack of complete certainty, that is, the existence of more than one possibility. My approach to making the canvas actionable was capturing that which was most uncertain, or more accurately, that which was most risky. “Startups operate under conditions of extreme uncertainty.” I had already been working with Lean Startup principles, which had a big influence on the design. The metaphor I had in mind was that of a ground-up tactical plan or blueprint that guided the entrepreneur as they navigated their way from ideation to building a successful startup. My main objective with Lean Canvas was to make it as actionable as possible while staying entrepreneur-focused. Lean Canvas also became a critical part of the methodology described in my book: Running Lean - first self-published as an ebook in February 2010, now being republished as a second edition O’Reilly title in March 2012. I recruited the help of other entrepreneurs to start building an online version of Lean Canvas with the initial goal of facilitating more of these learning conversations in my workshops and subsequently opening it up to everyone. I started using and testing Lean Canvas with other startups in my workshops and was particularly encouraged by its ability to enable more learning versus pitching conversations. I shared my adaptation (Lean Canvas) in a post I published: “ How I Document My Business Model Hypotheses.” This post quickly became one of my top posts of all time. I modeled my existing products at the time using both canvases, which prompted me to do some tinkering of my own that I’ll describe below. The thought of capturing business model hypotheses on a single page seemed killer. I had been using Steve Blank’s worksheets and struggled to keep them updated. It was not until I saw fellow entrepreneur Rob Fitzpatrick’s variation ( Startup Toolkit) that incorporated Steve Blank’s worksheets from “The Four Steps to the Epiphany” that I took a more serious look at the canvas. I was more interested in the “learning” that got them there. I was first exposed to the Business Model Canvas through Alex Osterwalder’s book: “Business Model Generation.” While I found the book beautifully illustrated, I originally dismissed the canvas approach as “too simple.” Many of the examples in the book illustrated the business models of well-known companies like Apple and Skype - after they were successful. Lately, this question has bubbled up in frequency which is why I decided to take the time to outline the thought process that went into creating Lean Canvas. I often get asked why I created a different adaptation from the original Business Model Canvas by Alex Osterwalder. Twitch is bigger than HBO Go, according to Sandvine’s traffic data Lyons, a reporter, novelist is now working on Season 2 of HBO’s Silicon Valley and he’s our guest this week. On this week’s Structure Show, Dan Lyons has lots to say about how Hollywood writers research and portray Silicon Valley, and what Fake Steve Jobs would think of the new Apple-IBM alliance.įake Steve Jobs: He’s back and we’ve got himĭan Lyons caused quite the kerfuffle when he started the Secret Diary of Steve Jobs 7 years ago. ICYMI: Why Apple and IBM make not-so-strange bedfellows Netflix’s prison drama Orange is the New Black is resonating with file sharers worldwide, but the streaming company is still trailing traditional broadcasters when it comes to piracy levels. Netflix’s Orange is the New Black got pirated more than 60 million times Peter Thiel gets over his long-time fear of Twitter, minutes before taking the TechCrunch Disrupt stage. It’s not quite the unbundling many HBO fans have been hoping for, but HBO Go is taking some first steps to bring… HBO is bringing HBO Go to legacy set-top boxes in Europe Since Snapchat Stories have been around for only a year or so, Snapchat celebrities are still a rare breed. Social media star Casey Neistat talks Snapchat versus YouTube He's bullish on ephemerality HBO CEO Richard Plepler took to the stage at the Apple Watch event Monday to officially announce the launch of HBO Now,… HBO officially announces April launch of HBO Now at Apple event At first, an Apple exclusive HBO Now is almost here: HBO officially announced plans to launch its online-only streaming service dubbed HBO Now during Apple’s spring event… Jon Stewart’s first HBO project teams him with ‘holographics’ startup Otoy (update) Updated!Īfter a short break concluding his legendary run on Comedy Central’s The Daily Show, former host Jon Stewart is heading to premium…Īll you need to know about HBO’s new HBO Now streaming service About that monthly price. Using the Visual Understanding Environment softwar.What does VUE stand for Abbreviation of VUE, definition of VUE, Explanation of VUE, Full forms of short form. On Point covers the Supplemental Nutrition Assista. VUE means Visual Understanding Environment.Visualizing Input-Output Data Using VUE from Tufts University - Online on Vimeo. The best way to understand the capabilities of this visualization tool is to watch this video, also available full-size on Vimeo. Accompanying data files and a processing program are available on my department's working paper series page. Our working paper (.pdf) gives instructions for using several practice data sets, or for downloading your own data from the federal government's Bureau of Economic Analysis (BEA). Visual Understanding Environment (VUE), a program that I have yet to discover the full potential of, has proven, for me, a useful tool in the translation of abstract non-symbolic concepts into symbolic, objective form as importantly, it has proven useful in taming the nonlinear beast of thought by corralling it into the linear format of the. VUE provides a flexible visual environment for. The VUE project is focused on creating flexible tools for managing and integrating digital resources in support of teaching, learning and research. I worked on this with Rebecca Nemec, Graham Jeffries, Mike Korcynski, and Jonelle Lonergan. Interactive Graphic Organizer - The Visual Understanding Environment (VUE) is Open Source downloadable mind mapping software based at Tufts University. This project extends the capability of Tufts University’s You can create your own diagram showing the industries and flows that you select, in any order you choose. The tool helped us make connections and identify similarities, links, and relationships between the theories.This new visualization tool allows you to explore resource flows between industries.įor example, you can see how much meat and poultry flows into the restaurant food industry, and then how much restaurant food flows to the final consumer (all measured in billions of dollars per year). While I keep notes for all my courses, it was very helpful to have this assignment because it helped me keep my thinking straight as we studied the wide variety of learning theories. The Visual Understanding Environment or VUE is a free, open source concept mapping application written in Java. One of the major assignments for this course was to create an ongoing map of the learning theories as we studied them using Visual Understanding Environment (VUE), a mind mapping tool developed by Tufts University. It reminds me of an advertising campaign by a watch company: “In order to break the rules, you first must master them.” I love the way we learn over time, from one generation to the next, building ideas and understanding through a time-travelling collaborationship, in that people’s ideas and contributions live on, though they are adapted and modified, in the theories of those that follow. I loved learning about the evolution of learning theory and the way successive theories build on what came before. This emphasized the need to interact with the learning and the interactive nature of the development of learning theory: a clear example of collaborationships, whereby what is developed together is greater than what is developed in isolation. In ETEC 512, we studied learning theories and the relationships between them. Chess is one of the most popular multiplayer games kids can learn easily. There are a lot of game websites for kids that provide chess as browser games for kids. And Chess is one of the best online games for kids out there now. It does not store any personal data.Chess is one of the oldest board games in the world. The cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. The cookie is used to store the user consent for the cookies in the category "Performance". This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Other. The cookies is used to store the user consent for the cookies in the category "Necessary". The cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional". The cookie is used to store the user consent for the cookies in the category "Analytics". These cookies ensure basic functionalities and security features of the website, anonymously. Necessary cookies are absolutely essential for the website to function properly. However, if you are looking for a tool that lets you easily download the generated Rebus puzzles as PDF or PNG file, then I will recommend. Apart from that, it also lets you use emojis instead of images to generate Rebus puzzles.Īlso Read: Android ListView Tutorial & Creating a Simple Android App. Out of these Rebus makers, I liked Festisite as it allows you to create Rebus puzzles in other languages as well. With this, we sum up our list of 4 best free online Rebus puzzle maker websites. You can also export the generated rebus puzzle as a PNG image. Visit the Rebus Club from the link below and specify a word or phrase and choose a difficulty level.Īfter that, click on the “MAKE IT!” button to generate a rebus puzzle. Therefore, if you want to create challenging Rebus puzzles, then you should check out Rebus Club. What sets it apart from other rebus puzzle makers on this list is that it allows you to choose the difficulty level for the Rebus puzzle. Rebus Club is another fantastic website that you can use to create Rebus puzzles easily. Just visit the link provided below and specify a word or phrase for which you want to create a rebus puzzle automatically.Īlso Read: How To Create Crosswords Using Google Sheets. To generate a rebus puzzle using this online tool is a pretty straightforward task. The best part of this online rebus maker is that it allows you to export the generated puzzle either as a PDF or PNG file. Rebuses is one of the best online rebus puzzle maker website. Once you are done, you can export the generated rebus puzzle as an image or PDF file to share it with your friends on social media and start having some fun. All you have to do is enter some words or sentences, and these rebus puzzle creators with generating the pictorial question. Getting started with these rebus puzzle maker tools is pretty straightforward. Both are in evident in Peter Grimes which is based on George Crabbe’s collection of poems The Borough (1810). Giving community a voiceįew composers of any nationality have possessed dramatic instincts as sure as Britten’s, or his extraordinary sensitivity to words. The company’s manager at the time, the soprano Joan Cross, was staunch in her support of Britten however, and despite a tense first night, the opera was an instant and enduring success. Peter Grimes had been chosen for the return of the Sadler’s Wells opera company to the theatre on Rosebery Avenue after the war, but there was a good deal of hostility within the company towards the new work. The first night of Peter Grimes at Sadler’s Wells a month after VE Day was arguably the most significant ever in the history of English opera. Revised for Brescia three months later though, the tragic tale began to exert a vice-like grip on audiences that has never been relaxed.ġ945: Peter Grimes by Benjamin Britten Opera after the War Having said that, the premiere of Madama Butterfly in Milan in 1904 was an outright failure – ‘a real lynching’ Puccini called it. Puccini was a keen theatre-goer and immediately spied the operatic potential of David Belasco’s one-act play Madame Butterfly: A Tragedy of Japan when he saw it in London in 1900. But if Puccini’s career was a sunset, it was glorious: together with the librettists Giacosa and Illica, Puccini wrote three of the most popular operas of all time: La Bohème (1896), Tosca (1900) and Madama Butterfly (1904). After his final, unfinished, opera Turandot premiered in 1926 no subsequent Italian opera gained a permanent place in the repertoire. The grand sweep of Italian Romantic opera, which had begun with Rossini in the 1810s, reached its terminus with Puccini. But the festival made such a stupendous loss that the Ring was never again performed there in his lifetime.ġ904: Madama Butterfly by Giacomo Puccini The end of Italian Romantic opera ‘“Next year, we’ll do it all differently” he said afterwards. It is hardly surprising that Wagner was dissatisfied with certain aspects of the Ring cycle’s execution at the first Bayreuth Festival. The result was arguably the single most ambitious artwork of the 19th century. Wagner aimed to immerse the audience in a ‘total work of art’ which fully integrated text, music, scenography and performance. The Ring circles around the conflicting impulses of power and love as it takes us from the birth of the world to its ending – and the possibility of a new beginning. Wagner himself described his works as ‘music drama’ but, like the first composers of opera, he found inspiration in myth (Norse-Germanic in his case), and, like them, he repurposed ideas about ancient Greek theatre. The Ring cycle – three operas, plus a ‘preliminary evening’ – was first performed over five days in August 1876 at the theatre Wagner had built specifically for the purpose in the small Bavarian town of Bayreuth. The Milanese audiences soon warmed up however, and by the end of the century, Norma had been performed in 35 countries in 16 different languages.ġ876: Der Ring des Nibelungen by Richard Wagner A cycle of operas Unfortunately, it only received a lukewarm reception on the first night at La Scala. When the time was up, Pasta decided that none were required. Apparently she was none too keen on it at first, so Bellini made her a deal: if, after she’d practiced it every day for a week, she still had doubts, he would rewrite the number to suit her better. Its most famous number is ‘Casta diva’ (‘Chaste goddess’) sung by the opera’s heroine. Norma is a classical tragedy set in Gaul during the Roman occupation. He was one of the finest purveyors of the ‘bel canto’ (literally, beautiful singing) tradition. 1831: Norma by Vincenzo Bellini Bel CantoĪlong with Rossini, Donizetti and, a little later, Verdi, Bellini helped establish the tradition of Italian Romantic opera that, for many people, goes to the heart of what opera is all about. For custom orders, allow three additional business days for processing. Saturday delivery is not guaranteed and subject to carrier availability. Inclement weather and holidays may cause shipping delays. Perfect for outdoor events and more, this sports tent is portable and lightweight. Stay dry and warmer no matter the weather. This weather tent is enclosed for warmth and comfort. The wider base and tapered sides blunt wind gusts. Ground shipments dispatch in 3-5 business days. MyPodXL pop-up shelter fits 1 person, a large chair and provides space for coolers and gear. 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It pops-up and folds down in a snap so you’reĪlways dry and cozy–no matter the weather.Calling sports fans, and outdoor enthusiasts! Say goodbye to annoying bugs and harmful UV rays and hello to worry-free outdoor activities with the 46x46 extra-large bug screen Pop-UP Pod–the ultimate portable bug-screen Pod. The ultra-soft, fine gauge bug screens and UPF 50-treated fabrics make this mesh bug-screen Pod a safe and comfortable space for you and your loved ones to relax and enjoy the outdoors. The weatherproof MyPodXL™ is durable, portableĪnd lightweight. Small folding chairs–plus a couple of kids, backpacks and aĬooler to boot. And it’s roomy enough for a soccer chair or two “connect” with family and friends while catching all the outdoor Non-tapered shape allows for side-by-side seating so you can also On three sides so you can connect two Pods at a time. The MyPodXL™ has a spacious modular design with zippered doors
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